Sulfuretin has therapeutic activity against acquired lymphedema by reducing adipogenesis.
Identifieur interne : 000155 ( Main/Exploration ); précédent : 000154; suivant : 000156Sulfuretin has therapeutic activity against acquired lymphedema by reducing adipogenesis.
Auteurs : Kangsan Roh [Corée du Sud] ; Suji Kim [Corée du Sud] ; Hee Kang [Corée du Sud] ; Jin-Mo Ku [Corée du Sud] ; Kye Won Park [Corée du Sud] ; Sukchan Lee [Corée du Sud]Source :
- Pharmacological research [ 1096-1186 ] ; 2017.
Abstract
Acquired lymphedema is a pathological condition associated with lymphatic dysfunction caused by surgical treatments for cancer. Although global estimates of the prevalence of acquired lymphedema have been rising, there are currently no effective therapeutics available. Since adipose tissue accumulation is a clinical hallmark of lymphedema, we hypothesized that regulation of adipogenesis in lymphedematous tissue could be used as a therapeutic intervention against lymphedema. Toward this, we investigated the possibility of anti-adipogenic 30% ethanol Rhus verniciflua Stokes (RVS) extract as a potential lymphedema treatment. Oral administration of RVS extract ameliorated volumetric symptoms of lymphedema in a mouse model. RVS administration also reduced adipose tissue accumulation in lymphedematous tissue and downregulated expression of adipocyte markers, including Pparγ and Fabp4. Sulfuretin was identified as a major bioactive compound in the 30% ethanol RVS extract in liquid chromatography-mass spectrometry analysis. Similar to the activities of RVS, sulfuretin inhibited adipocyte differentiation in 3T3-L1 preadipocytes. Moreover, treatment with sulfuretin on lymphedema-induced mice reduced lymphedema volume, decreased the expression of adipogenic markers, but induced the expression of markers associated with lymphangiogenesis. Taken together, our data raise the possibility that sulfuretin might be used in therapeutic interventions against acquired lymphedema.
DOI: 10.1016/j.phrs.2017.05.003
PubMed: 28483479
Affiliations:
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Electronic address: cell4u@skku.edu.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Genetic Engineering, Sungkyunkwan University, Suwon, 440-746</wicri:regionArea><wicri:noRegion>440-746</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pharmacological research</title><idno type="eISSN">1096-1186</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acquired lymphedema is a pathological condition associated with lymphatic dysfunction caused by surgical treatments for cancer. Although global estimates of the prevalence of acquired lymphedema have been rising, there are currently no effective therapeutics available. Since adipose tissue accumulation is a clinical hallmark of lymphedema, we hypothesized that regulation of adipogenesis in lymphedematous tissue could be used as a therapeutic intervention against lymphedema. Toward this, we investigated the possibility of anti-adipogenic 30% ethanol Rhus verniciflua Stokes (RVS) extract as a potential lymphedema treatment. Oral administration of RVS extract ameliorated volumetric symptoms of lymphedema in a mouse model. RVS administration also reduced adipose tissue accumulation in lymphedematous tissue and downregulated expression of adipocyte markers, including Pparγ and Fabp4. Sulfuretin was identified as a major bioactive compound in the 30% ethanol RVS extract in liquid chromatography-mass spectrometry analysis. Similar to the activities of RVS, sulfuretin inhibited adipocyte differentiation in 3T3-L1 preadipocytes. Moreover, treatment with sulfuretin on lymphedema-induced mice reduced lymphedema volume, decreased the expression of adipogenic markers, but induced the expression of markers associated with lymphangiogenesis. Taken together, our data raise the possibility that sulfuretin might be used in therapeutic interventions against acquired lymphedema.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Roh, Kangsan" sort="Roh, Kangsan" uniqKey="Roh K" first="Kangsan" last="Roh">Kangsan Roh</name></noRegion><name sortKey="Kang, Hee" sort="Kang, Hee" uniqKey="Kang H" first="Hee" last="Kang">Hee Kang</name><name sortKey="Kim, Suji" sort="Kim, Suji" uniqKey="Kim S" first="Suji" last="Kim">Suji Kim</name><name sortKey="Ku, Jin Mo" sort="Ku, Jin Mo" uniqKey="Ku J" first="Jin-Mo" last="Ku">Jin-Mo Ku</name><name sortKey="Lee, Sukchan" sort="Lee, Sukchan" uniqKey="Lee S" first="Sukchan" last="Lee">Sukchan Lee</name><name sortKey="Park, Kye Won" sort="Park, Kye Won" uniqKey="Park K" first="Kye Won" last="Park">Kye Won Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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